A number of pulsed lasers have been used in laser desorption/ionization techniques, including pulsed laser ablation (PLD), UV laser ablation (LPI), and infrared laser ablation (LASI). In these techniques, analyte ions are produced by ablating analyte materials with an energetic pulsed laser or an electrical field (including dielectric surface charging). The desorption ionization techniques include matrix-assisted laser desorption ionization (MALDI) and desorption electrospray ionization (DESI). A few of the most promising mass spectrometry techniques are secondary ion mass spectrometry (SIMS), surface-assisted laser desorption ionization (SALDI), and desorption electrospray ionization (DESI).
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